Value of enteral nutrition in improving the efficacy and nutritional status of patients with moderate to severe ulcerative colitis

Chen Zhe; Shen Lin; Wang Fen

doi:10.3969/j.issn.1674-3245.2024.06.006

Abstract：Objective To observe the effect of total enteral nutrition on the clinical outcomes and improvement of nutritional status in patients with moderate to severe active ulcerative colitis.Methods A total of 116 patients with ulcerative colitis treated from June 2022 to December 2023 were included in the study.They were randomly divided into two groups using stratified randomization,with 58 patients in the control group and 58 patients in the enteral nutrition group.Both groups were given mesalazine combined with enema according to the affected area of the lesion,and severe patients were given sufficient corticosteroids.The control group received routine low residue general diet,while the enteral nutrition group received full enteral nutrition.After 6 weeks,the modified Mayo score was used to evaluate the efficacy.The body mass index(BMI),triceps skinfold thickness(TSF),serum albumin(ALB),prealbumin(PAB),and hemoglobin(Hb)of patients before and after treatment were compared.Record adverse reactions of patients.Results The Mayo score of the enteral nutrition group was(3.13±2.28),which was lower than the control group's(4.82±2.93),and the effective rate was 87.93%,which was higher than the control group's 65.51%(t=3.466,χ2=8.158,P<0.05).After treatment,although the BMI and TSF of the enteral nutrition group were higher than those of the control group,there was no statistically significant difference between the groups.After treatment,the ALB,PAB,and Hb of the enteral nutrition group were higher than those of the control group(t=4.047,7.062,3.832,P<0.05).Conclusion Combining total enteral nutrition with moderate to severe active ulcerative colitis patients can improve their nutritional status and enhance treatment efficacy.