Analysis of influencing factors on in-stent restenosis after coronary stent implantation
Lu Rong
Wen Fangfang
Zhang Yuanshu
Yang Sa
Chen Ruirui
Zhang Wen
Abstract：Objective To analyze the influencing factors of in-stent restenosis(ISR)after drug-eluting stent(DES)implantation in coronary heart disease.Methods Patients who underwent percutaneous coronary stent implantation from April 2020 to March 2022 and had complete follow-up data were included consecutively.According to the follow-up results of coronary angiography,873 cases were divided into a non-ISR group,and 104 cases were in the ISR group.The general clinical data,laboratory and other auxiliary examinations,lesion location,lesion type,presence of calcification and other vascular conditions,and stent-related indicators such as the number,length,diameter,and serial connection of stents were compared between the two groups.Multivariate logistic regression analysis was performed.Results Smoking,poor medication adherence,TC,LDL-C,UA,regular exercise,bifurcation lesions,moderate to severe calcification,and stent diameter,which showed statistical differences in univariate analysis,were included in the logistic regression analysis.After removing collinearity,smoking,poor medication adherence,high LDL-C levels,bifurcation lesions,moderate to severe calcification,and small stent diameter were identified as risk factors for ISR,while regular exercise was a protective factor for ISR(P<0.05).Conclusion Bifurcation lesions,coronary artery calcification,thin stents,elevated LDL-C levels,patient smoking,irregular exercise,and poor medication adherence are risk factors for ISR in patients with coronary heart disease who have undergone DES implantation.Targeted strategies should be adopted to prevent ISR.
Keywords：Coronary heart diseaseDrug-eluting stentsIn-stent restenosisRisk factorsContinued care
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 562-564 )