Correlation and clinical value analysis of Ki-67,mutant p53 expression and CT with rectal adenocarcinoma subtype and degree of pathological differentiation
Sun Long
Yang Xiaofeng
Yu Lingling
Zhang Ying
Abstract：Objective To explore the correlation and clinical value of nuclear gene Ki-67,mutant p53 expression and CT with rectal adenocarcinoma subtype and pathological differentiation degree.Methods 90 patients with rectal adenocarcinoma admitted to our hospital from January 2021 to December 2022.The expression of Ki-67 and mutant p53 was determined by immunohistochemical method,and the patients were analyzed to explore the expression of Ki-67 and mutant p53 and the correlation between the CT result and the subject(ROC)curve to explore the diagnostic value of the indicators for highly differentiated rectal adenocarcinoma.Results According to the rectal adenocarcinoma subtype,90 patients were divided into group A(n=73,tubular adenocarcinoma)and group B(n=17,mucinous adenocarcinoma),and the patients were divided into group C(n=74,poorly differentiated)and group D(n=16,moderately and highly differentiated).The positive rates of Ki-67 were 76.71%and 47.06%in A and B,47.30%and 87.50%,respectively(χ2=4.547,8.573,P<0.05).The positive rates of mutant p53 were 53 in A,42%and 23.53%,respectively,and 36.49%and 81.25%in C and D,respectively(χ2=4.939,10.676,P<0.05).By physicians of CT imaging result between group C and D,tumor location,wall length,thickness,strengthening degree,enhanced low density area were not statistically significant(P>0.05),but compared with group C,group D wall bias,ring thickening,severe intestinal infiltration was large,and the difference was statistically significant(P<0.05).According to the above result,the ROC area under the positive expression of Ki-67 and mutant p53 and the ROC curve were 0.701,0.724,0.636,0.639,respectively,but the diagnosis of the intestinal wall-biased circular thickening and severe perienteral invasion was not statistically significant(P>0.05).Conclusion The positive expression of Ki-67 and mutant p53 has some diagnostic significance for the subtype and pathological differentiation of rectal adenocarcinoma,and the CT influence feature can reflect the degree of pathological differentiation of rectal adenocarcinoma patients to some extent,but the diagnostic value is low.
Keywords：Nuclear gene Ki-67Mutant p53CTRectal adenocarcinoma subtypeDegree of pathological differentiation
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 673-676 )