Correlation of serum S100B and HIF-1α levels with the condition and cognitive function of patients with epilepsy
Liu Yanyun
Qian Shaogui
Qian Junfeng
Abstract：Objective To investigate the correlation of serum S100 calcium binding protein B(S100B)and hypoxia-inducible factor-1α(HIF-1α)levels with the condition and cognitive function of patients with epilepsy.Methods 113 patients with epilepsy in our hospital from January 2019 to June 2022 were selected as the epilepsy group,and 45 healthy subjects were selected as the control group.The levels of serum S100B and HIF-1α in the two groups were detected.The correlation between serum S100B and HIF-1α levels and Montreal cognitive scale(MoCA)scores in patients with epilepsy was analyzed by pearson method.Results The serum levels of S100B and HIF-1α in the epilepsy group were significantly higher than those in the control group[(0.63±0.16)μg/L vs.(0.23±0.09)μg/L,(0.74±0.23)ng/ml vs.(0.35±0.12)ng/ml](t=15.949,10.551,P<0.05).The serum levels of S100B and HIF-1α and the score of NHS3 in patients with generalized seizures were significantly higher than those in patients with partial seizures[(0.68±0.17)μg/L vs.(0.60±0.15)μg/L,(0.84±0.25)ng/ml vs.(0.68±0.21)ng/ml,(14.16±3.06)points vs.(9.98±2.53)points](t=2.441,3.723,7.804,P<0.05).Compared with the patients with normal cognition,the patients with cognitive impairment had significantly higher serum levels of S100B and HIF-1α and NHS3 score[(0.73±0.16)μg/L vs.(0.59±0.14)μg/L,(0.91±0.29)ng/ml vs.(0.67±0.18)ng/ml,(13.52±3.26)points vs.(10.72±2.98)points],and had significantly lower MoCA score[(23.35±2.06)points vs.(28.43±1.16)points](t=5.025,5.240,4.374,16.854,P<0.05).The serum levels of S100B and HIF-1α were positively correlated with NHS3 score and negatively correlated with MoCA score in the epilepsy group(P<0.05).The area under the curve of serum S100B and HIF-1α combined diagnosis of cognitive dysfunction in epilepsy patients was 0.893,and the specificity and AUC of combined diagnosis were significantly higher than those of single detection(P<0.05).Conclusion The serum levels of S100B and HIF-1α are significantly increased in patients with epilepsy,and are closely related to the severity of the disease and cognitive status.Both S100B and HIF-1α can be used for the auxiliary diagnosis of cognitive impairment in patients with epilepsy.
Keywords：EpilepsyS100BHypoxia-inducible factor-1αCognitive function
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 617-620 )