Curative effect of cinacalcet and its influences on serum CKMB,cTnT and MYO in patients with moderate to severe secondary hyperparathyroidism after maintenance hemodialysis

Feng Caican; Jia Tingting; Wan Jun; Du Ruohong

doi:10.3969∕j.issn.1674-3245.2023.05.020

Abstract：Objective To observe the clinical curative effect of cinacalcet and the changes of serum creatine kinase MB(CKMB),cardiac troponin T(cTnT)and myohemoglobin(MYO)in patients with moderate to severe secondary hyperparathyroidism(MS-SHPT)after maintenance hemodialysis(MHD).Methods A total of 200 patients with MDD-MSSHPT admitted to the Shucheng People's hospital were enrolled and randomly divided into observation group(n=100,routine therapy combined with cinacalcet)and control group(n=100,routine therapy)between January 2021 and September 2022.All were treated for 12 weeks.Before treatment,after 6 and 12 weeks after treatment,levels of parathyroid function indexes[serum calcium(Ca),phosphorus(P),calcium-phosphorus product(Ca×P),intact parathyroid hormone(iPTH)]and cardiovascular function indexes(CKMB,cTnT,MYO)were detected.The adverse reactions during treatment were observed.Results After treatment,the serum levels of Ca,P,Ca×P,and iPTH in both groups decreased compared to before treatment,and the levels of these indicators in the observation group at 6 and 12 weeks after treatment were lower than those in the control group,with statistical significance(P<0.05).After treatment,the serum levels of CKMB,cTnT,and MYO in both groups decreased compared to before treatment,and the levels of these indicators in the observation group at 12 weeks after treatment were lower than those in the control group,with statistical significance(P<0.05).The total incidence of adverse reactions in the observation group was 15.00%,which was not statistically different from the 10.00%in the control group(P>0.05).Conclusion Cinacalcet can effectively reduce iPTH level,maintain steady state of calcium-phosphorus metabolism,protect cardiovascular function and improve clinical curative effect in MHD-MSSHPT patients,with good safety.