Relationship between serum APN,BDNF and cognitive function in patients with transient ischemic attack

Pan Xiaofan; Wang Dan; Li Gang

doi:10.3969∕j.issn.1674-3245.2023.05.008

Abstract：Objective To investigate the relationship between serum adiponectin(APN),brain-derived neurotrophic factor(BDNF)and cognitive function in patients with transient ischemic attack.Methods The clinical data of 108 patients with transient ischemic attack admitted to our hospital from January 2020 to January 2023 were retrospectively analyzed,and they were divided into cognitive dysfunction group(n=48)and normal cognitive function group(n=60)according to cognitive function.The value of serum APN and BDNF in predicting cognitive dysfunction in patients with transient ischemic attack was analyzed by receiver operating characteristic curve(ROC).Multivariate logistic regression analysis was used to determine the risk factors of cognitive dysfunction in patients with transient ischemic attack.Results The proportion of patients with years of education≤6 years,hypertension,diabetes and resting cavity infarction in cognitive dysfunction group was significantly higher than that in normal cognitive function group,and the serum APN and BDNF levels were significantly lower than those in normal cognitive function group(P<0.05).After ROC analysis,the areas under the curve of serum APN and BDNF to predict cognitive dysfunction in transient ischemic attack patients were 0.731 and 0.728(P<0.05),respectively.Multivariate logistic regression analysis showed that years of schooling≤6 years,hypertension,diabetes,resting infarction,APN≤6.120 μg∕ml,BDNF≤4.980 ng∕ml were risk factors for cognitive dysfunction in patients with transient ischemic attack(P<0.05).Conclusion Serum APN and BDNF are significantly correlated with cognitive function in patients with TIA,and lower levels of APN and BDNF predicted cognitive impairment in patients with TIA.