Efficacy analysis of hyperbaric oxygen combined with endovascular treatment of acute cerebral infarction
Liu Lin
Liu Xin
Dou Jingbin
Abstract：Objective To investigate the effect of hyperbaric oxygen combined with endovascular treatment on acute cerebral infarction(ACI).Methods A total of 134 patients with ACI in our hospital from January 2020 to December 2021 were randomly divided into an observation group and a control group,67 cases for each group.The control group was treated with vascular interventional thrombectomy,and the observation group was treated with hyperbaric oxygen combined with vascular interventional therapy.The clinical efficacy,cerebral blood flow perfusion[cerebral blood flow(CBF),cerebral blood volume(CBV)],blood oxygen saturation(SaO2),serum interleukin-1β(IL-1β),interleukin-6(IL-6)and monocyte chemoattractant protein-1(MCP-1)levels before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 91.04%(61∕67),which was higher than 77.61%(52∕67)of the control group(P<0.05).After treatment,the NIHSS score of the observation group was lower than that of the control group[(5.85±1.46)points vs.(9.28±2.04)points](t=10.573,P<0.05),and the mRS score of the observation group was better than that of the control group at 3 months of follow-up(χ2=4.772,P<0.05).The CBF,CBV and SaO2 in the observation group after treatment were higher than those in the control group[(22.86±2.49)ml∕(100 g·min)vs.(19.35±2.12)ml∕(100 g·min),(2.28±0.31)ml∕100 g vs.(1.96±0.29)ml∕100 g,(91.65±9.25)%vs.(84.26±6.96)%](t=7.797,7.776,4.669,P<0.05),and the serum levels of IL-1β,IL-6 and MCP-1 in the observation group after treatment were lower than those in the control group[(5.31±1.26)ng∕l vs.(6.08±1.38)ng∕l,(22.89±4.51)ng∕l vs.(28.63±5.04)ng∕l,(137.58±27.52)μg∕l vs.(161.87±28.76)μg∕l](t= 3.535,7.539,4.963,P<0.05).Conclusion Hyperbaric oxygen combined with vascular interventional therapy can improve cerebral blood perfusion and inhibit inflammatory response,thus improving the prognosis of ACI patients.
Keywords：Acute cerebral infarctionHyperbaric oxygenEndovascular interventional therapyCerebral blood flow perfusionInflammatory response
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 504-507 )