Clinical significance of early liquid therapy regimen in ICU perioperative elderly patients with hyperlipidemia

Li Qin; Hu Su; Li Li

doi:10.3969/.issn.1674-3245.2018.04.015

Abstract：Objective Through the use of early liquid therapy program for ICU perioperative elderly patients with hyperlipidemia liquid management,this study did an analysis of its therapeutic effect, with a view to provide a theoretical basis for clinical treatment. Methods 80 cases of perioperative elderly patients with hyperlipidemia were enrolled in this study. Intensive care unit(ICU) was divided into treatment group(40 cases) and control group(40 cases). The treatment group was treated with Ringer's solution 6.5 ml / kg.h for 6 hours after treatment. After 6 hours, patients were treated with conventional surgical rehydration. The control group was treated with conventional surgical rehydration only. Within the treatment group and control group, the levels of lactic acid at 6h,6h,24h,48h and 72h were measured at 6h,24h,48h and 72h after the patients were admitted to the intensive care unit. The acute kidney injury(AKI) incidence, the proportion of vasoactive drugs, the duration of treatment of mechanical ventilation, ICU stay and other items were measured according to the data comparison of the two treatment options. Results There was significant difference between the control group (2 438.6 ± 218.7) and the control group at the same time (1 834.7 ± 196.3) ml (P ＜ 0.05). At the 24h, 48h and 72h of the treatment group, (3 367.1 ± 316.4)ml, (6 058.4 ± 537.1)ml, (8 469.7 ± 547.3)ml, compared with the control group (3 428.6 ± 337.4) ml,(6 139.7 ± 521.8)ml,(8 635.1 ± 531.6)ml. (1.79 ± 0.42)mmol/L,(1.62 ± 0.58)mmol/L at the same time (2.09 ± 0.43) mmol/L. in the treatment group at the same time (P ＞ 0.05) (1.49 ± 0.51)mmol/L, (1.41 ± 0.43)mmol, respectively, and the difference was statistically significant (P＜0.05)(1.45 ± 0.47)mmol/L,(1.36 ± 0.37)mmol/L at the same time (2.81 ± 0.56)mmol/L, the difference was not statistically significant (P ＜ 0.05). The incidence of AKI in the treatment group was 15%, which was significantly higher than that in the control group(P＜0.05). The ratio of vasoactive drugs in the two groups was significantly higher than that in the control group (P ＜ 0.05). Duration, ICU time contrast, the difference was not statistically significant (P ＞ 0.05). Conclusion Early liquid therapy program for ICU perioperative elderly patients with hyperlipidemia liquid management therapy can reduce the incidence of acute renal injury, shorten the duration of hyperlipidemia, so it is worthy to perform on clinical application.