Effect of different anticoagulants in the treatment of blood purification and the effect on the coagulation function of the patients

doi:10.3969/.issn.1674-3245.2018.04.010

Abstract：Objective This study investigated the effect of different anticoagulants on blood purification and on the blood coagulation function of the patients. Methods We selected 80 cases of continuous blood purification (CBP) performed in the intensive care unit (ICU) of our hospital from July 2016 to June 2017. These patients were randomly divided into the normal heparin anticoagulant group (n=38) and the local citric acid anticoagulant group (n=42) by random digital table. We observed the blood coagulation function and biochemical indexes and etc before and after treatment. Results The blood urea nitrogen (BUN), creatinine (Scr), alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in local citric acid anticoagulation group after treatment were(10.11 ± 3.02)mmol/L,(155.40 ± 42.39)mmol/L,(67.39 ± 20.04)U/L and(65.51 ± 23.21)U/L,were significantly lower than that of normal heparin group(P ＜ 0.05);The prothrombin time(PT),activated partial thromboplastin time(APTT) and thrombin time(TT) in local citric acid anticoagulation group were(13.20 ± 3.20),s(40.12 ± 10.21)s and(20.11 ± 8.38)s,were significantly lower than the normal heparin group(P＜0.05);There was no significant difference in APACHE II score before and after treatment between local citric acid anticoagulant group and normal heparin anticoagulant group (P＞0.05);The filter life span and the daily treatment cost of the localcitric acid anticoagulant group were(46.92 ± 9.11)hand(489.29 ± 67.39)yuan,which was significantly higher than that of the normal heparin anticoagulation group (P ＜ 0.05). Conclusion Heparin and citric acid anticoagulation are effective in CBP, citric acid can significantly improve coagulation function, liver and kidney function, and prolong filter life.