Effect of intensive hypoglycemic therapy on prognosis and blood glucose in patients with post-stroke hyperglycemia

doi:10.3969/.issn.1674-3245.2018.04.004

Abstract：Objective This study investigated the effect of intensive hypoglycemic treatment on prognosis and blood glucose in patients with hyperglycemia after ischemic stroke. Methods A total of 120 patients with ischemic stroke and hyperglycemia were enrolled in our hospital from July 2016 to January 2018. 60 patients were given conventional hypoglycemic methods (control group), and another 60 patients were given intensive hypoglycemic method. NIHSS,modified Rankin score (mRS),daily living ability score (ADL) and blood glucose related indicators before and after treatment in two groups were compared. Results The differences of FPG,SBP and DBP in the two groups were not statistically significant before treatment (P ＞ 0.05). After the treatment of 24h,the FPG,SBP and DBP of the enhanced group were significantly lower than those of the control group (P ＜ 0.05). NIHSS scores of the two groups had no statistical significance before treatment (P ＞ 0.05). On the 7th day and 14th day after treatment,NIHSS scores of the intensive group were significantly lower than those of the control group (P ＜ 0.05). 3 months,6 months after treatment,the mRS score of the intensive group was significantly lower than that of the control group(P＜0.05),and the ADL score of the intensive group was significantly higher than that of the control group (P ＜ 0.05)-6,CRP levels were not statistically significant (P ＞ 0.05). After treatment,the levels of serum IL-6 and CRP in the intensive group were significantly lower than those in the control group(P＜0.05). Conclusion Patients with hyperglycemia after ischemic stroke treatment with intensive hypoglycemic treatment can effectively control blood glucose,thereby reducing stress response,improve neurological function and prognosis of patients.