The effect of somatostatin,omeprazole combined with psychological nursing intervention in the treatment of acute pancreatitis and its effect on serum inflammatory factors

Yang Huiqing

doi:10.3969/.issn.1674-3245.2018.03.018

Abstract：Objective To explore the clinical efficacy and serum inflammatory factors of somatostatin and omeprazole after acute pancreatitis.Methods From May 2016 to May 2017,90 cases of acute pancreatitis in our hospital were enrollde and randomly divided into the control group(somatostatin,omeprazole combined with routine treatment)and the observation group(somatostatin,omeprazole combined with psychological nursing intervention treatment),45 cases of patients in each group.The recovery of clinical symptoms and the influence of negative emotions such as anxiety were compared after the treatment.Results After the treatment,the mental support,psychological counseling,medication safety and puncture nursing were significantly better in observation group than those in the control group,and the differences were statistically significant(P ＜ 0.05).The expressions of CRP(40.28 ± 9.11)mg/L,IL-6(44.81 ± 5.99)ng/L,IL-10(46.55 ± 2.21)ng/L and TNF-α(51.77 ± 6.24)ng/Lin observation group were significantly lower than those in control group with CRP(60.31 ± 8.22)mg/L,IL-6(61.88 ± 6.01)ng/L,IL-10(52.75 ± 3.81)ng/L and TNF-α(67.81 ± 9.994)ng/L.The abdominal pain relief time(2.88 ± 0.43)d,intestinal function recovery time(1.44 ± 0.38)d,hospitalization time(12.87 ± 2.55)d in observation group were significantly shorter than the abdominal pain relief time(4.56 ± 0.23)d,intestinal function recovery time(3.81 ± 0.54)d,hospitalization time(18.99 ± 3.01)d in control group,and the differences were all statistically significant(P＜0.05).Conclusion In patients with acute pancreatitis,the combination treatment of somatostatin,omeprazole and psychological nursing can effectively eliminate inflammatory factors in the serum,improve patient satisfaction and have high clinical application value.