Relationship between serum total bilirubin levels and prevalence of metabolic syndrome in elderly men

doi:10.3969/.issn.1674-3245.2018.03.009

Abstract：Objective To investigate the correlation between serum total bilirubin level and metabolic syndrome and its components in elderly men.Methods 430 cases of elderly male hospitalized patients were included,including 227 cases of metabolic syndrome group and 203 cases of non metabolic syndrome group.At the same time,all the subjects were divided into 5 groups according to the number of abnormal metabolic disorders.The general conditions and indicators of all the subjects were recorded,including height,body mass(BMI),total bilirubin(TB),liver function,blood sugar,blood lipids,uric acid and other biochemical indicators.Results According to the comparison of the serum TB level between the five groups,there is a significant difference between the five groups(P ＜ 0.001),and the serum TB level of the two metabolic abnormalities coexist group was significantly increased than in other groups(P＜0.05);The serum total bilirubin level was negatively correlated with hyperlipidemia,diabetes and hypertension(r=-0.181,P=0.001;r=-0.21,P=0.001,r=-0.155,P=0.001).Metabolism syndrome risk factors multivariate logistic regression analysis showed:elderly male serum TB level was negatively correlated with metabolism syndrome(OR:0.943,95％CI:0.892-0.997;P=0.04).Serum TB level was negatively correlated with hypertension(OR:0.948,95％CI:0.940-0.999;P=0.048).Serum TB level was negatively correlated with hyperlipidemia(OR:0.943,95％CI:0.898-0.991;P=0.021).Serum TB level was negatively correlated with diabetes(OR:0.953,95％CI:0.909-0.998;P=0.042).According to the four percentile of serum total bilirubin level,it was found that the proportion of metabolic syndrome,hypertension,hyperlipidemia and diabetes decreased with the increased total bilirubin level.Conclusion The low level of serum total bilirubin in physiological range may be an independent risk factor in elderly men,and the total bilirubin level in serum physiological range is negatively correlated with the metabolic syndrome and its components hypertension,hyperlipidemia and diabetes.