The clinical effects and safety of puerarin injection in patients with sudden deafness
Yang Wei
Liu Yafeng
Zhou Zhiqiang
Abstract：Objective To explore the clinical effects and safety of puerarin injection in patients with sudden deafness. Methods One hundred twenty-two cases of sudden deafness were randomly divided into the control group(61 cases)and experiment group (61 cases). The two groups were given conventional treatment and symptomatic treatment. The control group was given ligustrazine hydrochloride injection 80 mg + normal saline 500 ml intravenous drip,1 time per day. The experiment group was given puerarin 0.6 g + glucose injection 250 ml intravenous infusion,1 time per day. Clinical efficacy,serum lipid peroxide(LPO), superoxide dismutase(SOD),6-keto-prostaglandin F1a(6-Keto-PGF1a)and thromboxane B2(TXB2)levels and the incidence of adverse reactions were compared. Results After treatment,the total effective rate of the control group(83.61%)was significantly lower than that of the experiment group(95.08%)(P<0.05).The levels of LPO and TXB2in serum were significantly decreased after treatment in both groups,with the experiment group being lower than the control group(P < 0.05). The levels of SOD and 6-Keto-PGF1ain serum were significantly increased,with the experiment group having significantly higher levels than the control group(P <0.05).The adverse reaction rate in the control group was 11.48%,and that of the experiment group was 6.56%,but the difference was not statistically significant(P>0.05).Conclusion Puerarin is effective and safe for the treatment of sudden deafness.
Keywords：PuerarinSudden deafnessClinical studySafety
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 144-146 )