Effects of two different anesthesia methods on the levels of tumor necrosis factorα,C-reactive protein and T lymphocyte subsets after resection in patients with hepatocellular carcinoma
Yuan Qingming
Abstract：Objective To investigate the effects of two different anesthesia methods on the levels of tumor necrosis factorα, C-reactive protein and T lymphocyte subsets after resection of hepatocellular carcinoma. Methods Sixty-eight patients with primary liver cancer admitted in our hospital from December 2013 to October 2014 were selected for this study. The patients were randomly divided into the propofol intravenous anesthesia group and the sevoflurane inhalation anesthesia group. The patients were treated with propofol intravenous anesthesia and sevoflurane inhalation anesthesia. The operation-related indexes of the patients were observed, and the changes of the surgical indicators,tumor necrosis factorα,C-reactive protein and T lymphocyte subsets were observed before and after anesthesia,1 day after anesthesia and 3 days after anesthesia. Results There was no significant difference in operation time,intraoperative blood loss,anal exhaust time or hospitalization time between the two groups (P> 0.05).②The differences in the TNF-αlevels were statistically significant(P<0.01),but there was no significant difference between the two groups(P>0.05). After 1 day and 3 days,TNF-αlevels of the two groups were higher than before anesthesia,and the difference was statistically significant(P< 0.01),and propofol intravenous anesthesia group TNF α under sevoflurane inhalation anesthesia group,and the difference was statistically significant (P < 0.05). ③There was no significant difference between the two groups (P > 0.05),but there was no significant difference between the two groups (P > 0.05).The CRP of the two groups after anesthesia was higher than that before anesthesia(P<0.01). The CRP in the propofol intravenous anesthesia group was lower than that in the sevoflurane anesthesia group, and the difference was statistically significant (P<0.05). ④The CD3+,CD4+ and CD4+/CD8+ levels of the two groups were lower than those before the operation and 1 day after operation,and the difference was statistically significant (P< 0.05). There were no significant differences in the level of CD3+,CD4+,and CD4+/CD8+between the two groups at 3 days after the operation (P>0.05). Conclusion To a certain extent,compared to sevoflurane inhalation anesthesia,propofol intravenous anesthesia reduce the body's inflammatory response to the weakened T lymphocyte immune function and improve the prognosis in patients with liver cancer.
Keywords：AnesthesiologyHepatectomyTumor Necrosis FactorαC-reactive ProteinT Lymphocyte Subsets
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 509-512 )