Burn combined COPD patients with secondary fungus infection incidence and related risk factors and pathogenic bacteria distribution analysis

Zhang Qinxue

doi:10.3969/.issn.1674-3245.2017.05.017

Abstract：Objective To explore burn combined Chronic Obstructive Pulmonary Disease (COPD) patients with secondary fungus infection incidence、related risk factors、pathogenic bacteria distribution. Methods Selected 800 cases of COPD patients, including burn combined 37 cases of COPD patients in our hospital from June 2013 to September 2016. Analyzed pathogenic bacteria distribution and drug resistance of fungal infection in patients with clinical symptoms,and found the COPD of secondary pulmonary fungal infection of the susceptible factors,factors of risk among multiple factors Logistics regression analysis. Results By sputum cell culture were detected pathogens,41 cases among them is given priority to with candida albicans,26 strains (63.41%) were detected;Fungi of antimicrobial resistance from high to low in turn for:ketoconazole(53.66%) and nystatin(43.9%),fluorine cytosine(29.27%), amphotericin B (24.39%),itraconazole (17.07%) and ketoconazole high than other antimicrobial drug resistance. The main clinical symptoms were cough(89.19%),expectoration(70.27%),fever(48.65%). Among these factors, including patients' age,length of hospital stay,hormone type and period of treatment,antibacterial drug kinds and treatment course of COPD,plasma albumin susceptible factors of secondary pulmonary fungal infection, we found that length of hospital stay,hormone treatment,lower plasma albumin were the risk factors for the secondary pulmonary fungal infection of COPD after logistics analysis. Conclusion Candida albicans is the common secondary fungal infection in patients with burn and COPD. Patients with COPD should be given effective prevention measurements for preventing the secondary fungal infection. Early detection and early treatment of fungal infection is very important.