The effect of hyperlipidemia on the pathogenesis of acute pancreatitis
Abstract：Objective To explore the effect of hyperlipidemia on the pathogenesis and prognosis of acute pancreatitis. Methods 365 inpatients with acute pancreatitis (AP) were enrolled in the study from January 2009 to June 2015. These patients were divided two groups, 263 patients in the mild acute pancreatitis group(MAP) and 102 patients in severe acute pancreatitis(SAP). Standard therapy was given to each patient. The complaints, serum and urine amylase, serum triglyceride and cholesterol were all recorded before and after treatment (day o,3 and 5 days) were recorded. Finally,curative effect and average hospitalized time was analyzed. Results 44.9% AP patients had hyperlipidemia. more common in satiation and drinking as an incentive. BMI、MCTSI and APACHE-II scores of patients with hyperlipidemia were respectively 26.7 ± 4.6,7.3 ± 2.8 and 3.9 ± 3.8,and these scores were higher than those of patients with normal serum lipid (respectively 24.7 ± 6.9,6.8 ± 2.0 and 3.2 ± 3.0)(P < 0.001). Before treatment, the base level of triglyceride in SAP was higher than in MAP (P < 0.05). And the level of serum amylase, urine amylase and cholesterol was no difference between two groups.The serum lipid level and APACHEII were decreased dramatically at 5 days after treatment. The effective rate was 74.2% in SAP, that was lower than the effective rate in MAP (83.3%).Moreover, the average hospitalized time in SAP was (25.7 ± 13.4) days, that was longer than that in MAP (21.3 ± 12.9 days) (P < 0.05). Conclusion Hyperlipidemia is one of the most important pathogenic factors of AP. Serum triglyceride might be an important marker on evaluating conditions and prognosis of acute pancreatitis.
Keywords：Acute pancreatitisHyperlipidemiaHypercholesteremiaEtiology
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 388-391 )