The application of 18F-FDG PET/CT imaging for cancer screening in asymptomatic individuals
Abstract：Objective To evaluate the potential application of 18-fluorodeoxyglucose positron emission tomography computed tomography (18F FDG PET-CT) for cancer screening in asymptomatic individuals. Methods We conducted a prospective analysis of asymptomatic individuals using 18F-FDG PET/CT to screen for cancer in the Health Management Institute of PLA General Hospital from January 2011 to December 2014. A total of 4899 subjects were enrolled, with a mean age of 51.8 ± 9.5 years, including 3390 males (69.2%) and 1509 females (30.8%). Results Malignant tumours were discovered in 72 cases among 13 organs, including the lung, thyroid and colon. The cancer detection rate was 1.5%. PET/CT false-negative results were identified in 8 cases, and PET/CT false-positive results were identified in 65 cases. PET/CT screening had a sensitivity of 90.0% and a specificity of 99.8%. The positive predictive value and the negative predictive value were 52.6% and 98.4%, respectively. Conclusion 18F FDG PET/CT has the potential to detect a wide variety of cancers at curable stages in asymptomatic individuals receiving check-ups. To reduce false-positive and false-negative results, ultrasound (thyroid gland and the liver) and endoscopy are also needed for cancer screening in addition to FDG PET/CT.
Keywords：Cancer screening18F-FDG positron emission tomography-computed tomographyCheck-up
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 337-339 )