Clinical study on the treatment of deepⅡdegree burn with removing scab ointment

doi:10.3969/.issn.1674-3245.2017.03.013

Abstract：Objective To evaluate the efficacy and safety of the application of the scab she patients with deep Ⅱ degree burning. Methods Randomized,single blind,blinded,positive drug controlled,single center,non inferiority clinical trial. 42 patients with deep Ⅱ degree burn wound within 7 days of burning were observed and studied. The wounds were divided into experimental group and control group,the scab ointment was used in the experimental group,and the control group was treated with hydrogel. Beginning the observation on the third day after treatment,record every 2 days for healing area ratio,wound healing time,the ratio of necrotic tissue and total wound area,whether or not there was wound infection,erythra,maceration and pruritus,evaluation of the pain visual analogue scale. the results in 21 days as the end of observation to assess the above items. We also test the blood routine,liver and kidney function and serum calcium for safety evaluation at the beginning and the Wound healing. Results The average healing time in experimental group was 13.88 days,and there was no significant difference compared with the control group (P > 0.05). No drug related side effects on blood routine,liver and kidney function and serum calcium level. d ointment in the treatment of Conclusion Scab shed ointment can speed up the wound healing in the patients with deep Ⅱ degree burning. The efficacy and safety is not less than that of hydrogel.