Clinical application of PCT dynamic changes in anti-infective therapy in senile patients with heart failure
Abstract：Objective To study the clinical value of serum procalcitonin (PCT) concentration in elderly patients with heart failure during the treatment of anti-infective therapy. Methods A total of 200 elderly patients with heart failure who were treated in ICU from February,2015 to March,2016 were randomly divided into two groups:experimental group (PCT) and control group (conventional treatment group) people. The two groups of patients were routine treatment,the control group of patients by physician analysis to determine the best time to use antimicrobial therapy,the experimental group by a certain number of elderly patients with heart failure after admission in the first 1,3,7,14 days. Analysis of changes in PCT concentration to determine whether anti-infective treatment of patients with the use of antimicrobial drugs. Observe the two groups of patients with antibiotic treatment,hospital stay, hospital costs,double infection rate and other indicators. Results There were no significant differences in age,sex,course of disease, LVEF and leukocyte between the two groups. Among the pathogens isolated from the two groups,klebsiella pneumoniae,acinetobacter baumannii,the number of pseudomonas aeruginosa was the highest,the average hospitalization cost of the experimental group was lower than that of the control group. The course of antimicrobial treatment was significantly lower in the experimental group than that in the control group. The dosage and cost of the antibiotics in the experimental group were lower than the control group ,The infection rate was 7% in the control group and 3% in the control group. The difference was statistically significant (P < 0.05). Conclusion PCT dynamic changes in the elderly patients with severe heart failure to guide the use of antimicrobial agents have a certain significance,according to the level of PCT changes to determine whether the use of antibiotics,whether to disable antibiotics,and evaluate the efficacy of antibiotics. In ICU elderly patients with heart failure in the treatment of anti-infection treatment of PCT concentration changes in the use of drugs,can reduce the use of antimicrobial drugs and hospital stay and drug resistance.
Keywords：ProcalcitoninHeart failureAntimicrobial agents
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 201-203 )