Influences of ERCC1,p53 and bcl-2 expression on the therapeutic effects of advanced NSCLC patients with platinum-based chemotherapy
Abstract：Objective The aim of this study was to assess the influences of ERCC1,p53 and bcl-2 expression levels on the therapeutic effects of terminal NSCLC platinum-based chemotherapy. Methods ERCC1,p53 and bcl-2 protein expression levels were assessed in patients' peripheral blood serum; the influencing factors of the curative effects of platinum-based chemotherapy on NSCLC patients were assessed, and the relationship between the expression levels of the three genes and their curative effects were analyzed. Results The chemotherapy efficiency of ERCC1 negative expression and ERCC1 positive expression were 55.81% and 25.58%, respectively (P<0.01),those of bcl-2 were 45.28%and 25.00%, respectively (P<0.05), and those of p53 were 53.85%and 29.79%, respectively (P < 0.05). There were no obvious correlations between ERCC1,p53 and bcl-2 expression levels; the effectiveness of chemotherapy was highest in patients with ERCC1 negative expression ,bcl-2 positive expression and p53 negative expression,compared with other situations; a significant difference was found (P < 0.05). The effectiveness of chemotherapy was lowest when the expressions of ERCC1,p53 and bcl-2 were positive (P < 0.01). Conclusion In serum,the expression levels of ERCC1,p53 and bcl-2 can be considered indicators of the therapeutic effects of platinum-based chemotherapy in NSCLC patients.
Keywords：NSCLCERCC1p53bcl-2Platinum chemotherapyGene
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 148-152 )