Impact of IL-6,IL-8,IL-10 and hepatorenal function in patients with serious burn treated with ulinastatin
Liu Che
Abstract：Objective To examine the impact on IL-6,IL-8,IL-10 and hepatorenal function in patients with serious burns that have been treated with ulinastatin. Methods Seventy-eight patients with serious burns who were admitted to the hospital from January 2009 to January 2013 were analyzed retrospectively. According to different treatment methods ,36 patients were assigned to a control group, and 42 patients were assigned to an observation group. The two groups were treated with conventional treatments for anti-shock,anti-infection,the management of burn wounds,nutritional support and symptomatic treatments. The control group was treated with 500 ml 0.9%NaCl,and the observation group was treated with 30 KU ulinastatin. The levels of ALT,BUN,SCr,IL-6,IL-8 and IL-10 were measured before and after treatment in the two groups. Results The levels of IL-6 were (165.51 ± 26.28) and (43.67 ± 6.76) in the observation group after treatment for 3 and 7 d, respectively;levels in the control group were (179.36 ± 25.98) and (62.85 ± 7.08), respectively,and the differences were statistically significant (P < 0.05);The levels of IL-8 were (112.25 ± 15.75) and (56.76 ± 8.04) in the observation group after treatment for 3 and 7 d, respectively;these values were notably lower than those in the control group,and the differences were statistically significant (P<0.05);The level of IL-10 were (28.24 ± 6.12) and (9.54 ± 2.04) in the observation group after treatment for 3 and 7 d, respectively;those in the control group were (21.76 ± 5.24) and (6.56 ± 0.47),respectively, and the differences were statistically significant (P<0.05). Conclusion The inhibition of inflammatory reaction in patients with serious burns by Ulinastatin might occur through lowering the levels of IL-6 and IL 8 and raising the levels of IL-10. Ulinastatin can reduce liver and kidney damage in patients with serious burns.
Keywords：UlinastatinBurnHepatic and kidney functionSerum cell factor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 142-144 )