Impact of expectant treatment in patients with early onset severe preeclampsia and FGR on serum soluble endoglin level

Pang Qi

doi:10.3969/.issn.1674-3245.2017.01.011

Abstract：Objective To explore the curative effect and impact of on serum soluble Endoglin level of expectant treatment in patients with early onset severe preeclampsia (EOSPE) and fetal growth restriction (FGR). Methods 68 cases of EOSPE and FGR patients who had expectant treatment in our hospital from January 2012 to June 2015 were selected as the study group ,and the other selected 30 healthy pregnant women in the same gestational weeks were selected as the control group. Enzyme-linked immunosorbent method was applied to detect the serum sEng levels of control group when selected and the study group before treatment and at 1d and 3d after treatment. A pregnancy outcome of the study group was statistically calculated and the serum sEng levels of the EOSPE and FGR women with adverse pregnancy outcome and normal pregnancy outcomes during treatment were compared. Spearman unconditionally correlation analysis was applied in analyzing the relationship between serum sEng level of EOSPE and FGR patients with the pregnancy outcome,and ROC curve was applied in analyzing the value of serum sEng levels predicting pregnancy outcome of patients with EOSPE and FGR. Results Serum sEng levels of the study group before the treatment was (5.88 ± 0.59) ng/mL,which was higher than the (1.21 ± 0.24) ng/mL of control group and the (3.96 ± 0.39) ng/mL and (3.18 ± 0.35) ng/mL of the study group after treated with 1d and 3d (P < 0.05). The incidence of adverse pregnancy outcomes, including fetal distress,neonatal asphyxia, neonatal death,neonatal pulmonary hyaline membrane disease and fetal intrauterine were 67.65%. And serum sEng level of the patients with adverse pregnancy outcomes before and after treatment were relatively higher than that of the patients with normal pregnancy outcomes (P < 0.05). Spearman unconditionally correlation analysis results showed that serum sEng level of the patients with EOSPE and FGR was positively correlated with the adverse pregnancy outcomes incidence of(r=0.768,P<0.05). Conclusion Serum sEng level of patients with EOSPE and FGR is high and expectant treatment can reduce the serum sEng level. The serum sEng level is closely related to the pregnancy outcome and the value of serum sEng level predicting the pregnancy outcome is fine. This can be related to sEng as angiogenesis inhibiting factor can cause vascular disorders associated with endothelial dysfunction , therefore,it is possible that sEng as reference index for the prediction of pregnancy outcome of patients with EOSPE merger FGR.