Mechanism of Rhodiola rosea in alleviating intracranial hypertension under microgravity conditions based on network pharmacology and molecular docking techniques
CUI Derong
GUO Haiyan
Abstract：Objective To explore the key targets and underlying mechanisms of Rhodiola rosea in alleviating intracranial hypertension and protecting astronauts'vision using network pharmacology and molecular docking techniques.M ethods Common targets between Rhodiola rosea and intracranial hypertension were screened to construct a"Herb-Chemical Component-Common Target"network and a protein-protein interaction(PPI)network,identifying active components and core targets of Rhodiola rosea for treating intracranial hypertension.Functional enrichment analysis was performed to elucidate associated biological pathways.Molecular docking was conducted to validate the binding affinity between active components and key targets.Results The active components of Rhodiola rosea against intracranial hypertension were identified as kaempferol,gallic acid,7-hydroxycoumarin,and salidroside.The core targets included serine/threonine kinase 1(Akt1),tumor protein P53(TP53),beta-actin(ACTB),nuclear factor kappa B1(NF-κB1),and HSP90AA1.Functional enrichment analysis determined 848 functional terms and 152 related pathways.Molecular docking results indicated strong binding affinities between gallic acid and TP53,kaempferol and Akt1,and 7-hydroxycoumarin with Akt1.C onclusion Rhodiola rosea may alleviate intracranial hypertension and protect astronaut vision under microgravity conditions by modulating the key targets Akt1,TP53,ACTB,NF-κB1,and HSP90AA1 through its active components—kaempferol,gallic acid,7-hydroxycoumarin,and salidroside,thereby influencing the PI3K/Akt1 and NF-κB signaling pathways.
Keywords：network pharmacologymolecular docking technologyRhodiola roseacranial hypertensionmechanism of action
Publication Date：2026-02-25
Online Publishing Date：2026-03-26(First online date of this platform, not the publication date of the document)
Pages：7( 1-7 )