Advance in mitochondrial dysfunction and bone loss in the microgravity environment
HUANG Qiyu
LU Liang
LI Kai
WANG Liqing
YANG Fan
PAN Rumo
LIN Xue
LI Jian
Abstract：Due to the effects of microgravity,astronauts experience significant bone loss during spaceflight.This bone loss increases the risk of osteoporosis and fractures,posing a serious threat to astronauts'skeletal health and their capability to undertake long-duration space missions.Research has shown that mitochondria-mediated metabolic regulation can sense microgravity stress,modulate multiple signaling pathways,and trigger early cellular responses.This review summarizes the mechanisms by which mitochondrial dysfunction contributes to bone loss in both real and simulated microgravity environments,as well as the progress in existing drug studies.It provides a theoretical foundation for developing new bone-protective strategies targeting mitochondria.
Keywords：microgravitymitochondriabone lossoxidative stress
Publication Date：2025-12-25
Online Publishing Date：2026-01-15(First online date of this platform, not the publication date of the document)
Pages：8( 560-567 )