Exploring the etiology,pathogenesis,prevention and treatment of cardiac remodeling in microgravity based on the trinity view of"Physique-Qi-Spirit"
Yan Sitong
Liu Luyang
Wang Jiarou
Zhou Kailong
Tian Peng
Nan Qian
Sun Huiyuan
Abstract：Cardiac remodeling in microgravity exerts effects on astronauts'health and space mission efficiency.This paper analyzes the etiology,pathogenesis,prevention,and treatment of cardiac remodeling in microgravity based on the Trinity View of"Physique-Qi-Spirit"of traditional Chinese medicine.The microgravity environment disrupts the heaven-earth qi interaction law described in"Suwen Yin Yang Ying Xiang Da Lun":"Earth qi ascends to form clouds through heavenly evaporation,while heaven qi descends as rain".This disruption causes upward reversal of human qi and cephalad fluid shift,consequently influencing the dynamic balance of the physique-qi-spirit system and inducing cardiac remodeling.The core pathogenesis initiates with qi upward reversal at the initial stage,advances through spiritual disturbance during progression,and culminates in physical impairment at the terminal stage.We therefore propose a holistic"physique-qi-spirit"co-regulation strategy implemented via three therapeutic principles:regulating qi,stabilizing spirit,and restoring physique.This approach aims to restore the dynamic balance of the"physique-qi-spirit"system in microgravity,apply the concept of"preventive treatment of diseases",holistically prevent or delay cardiac remodeling,and provide Traditional Chinese Medicine solutions for safeguarding astronauts'cardiovascular health.
Keywords：Physique-Qi-Spiritmicrogravitycardiopulmonary remodelingetiology and pathogenesisprevention and treatment
Publication Date：2025-10-25
Online Publishing Date：2025-11-13(First online date of this platform, not the publication date of the document)
Pages：6( 458-463 )