Mitochondria-The intracellular receptors for spatial microgravity
Chen Lerong
Wang Pengxiao
Wang Zhen
Long Jiangang
Abstract：The weightlessness effect during space flight can cause damage to the astronaut's body,and this damage requires a longer recovery time even after the astronaut returns to Earth,and even irreversible damage may occur.Mitochondria are important organelles within cells,participating in regulating a range of important physiological and biochemical processes.Mitochondrial mediated metabolic regulation can sense microgravity stress,which is an early intracellular response caused by microgravity,promoting the adaptation of intracellular metabolism and stress-induced damage.This article reviews the research progress on the effects and related mechanisms of microgravity and simulated microgravity on cell mitochondria,providing a theoretical basis for the development of protection strategies targeting mitochondria.
Keywords：microgravitysimulated microgravitymitochondriametabolic regulation
Publication Date：2024-08-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 258-267 )