Study on Functional Brain Network of Schizophrenia P50 Sensory Gating based on Granger Causality
Zu Hongyue
Wang Suogang
Tan Shuping
Abstract：Objective To analyze the sensory gating state brain networks connectivity specificity of the schizophrenia from the functional connectivity of the multi-channel EEGs.Methods The study involved 10 chronic schizophrenics and 10 healthy controls and the condition-test stimuli paradigm was used.The Causal connection matrixes in delta,theta,alpha,low-beta,and high-beta and gamma band were calculated by the Directed Transform Function (DTF) based on the granger causality analysis.Thereafter the flow gain at different bands were calculated and discussed by using the graph theoretic parameters.Results In high-beta and gamma band,DTF (P ＜ 0.001),the clustering coefficient (high-beta,P ＜ 0.001;gamma,P ＜ 0.01),and the global efficiency (P ＜ 0.001) were significantly higher in schizophrenia patients as compared with the control subjects.Moreover,there were significant differences in schizophrenia patient's flow gain as compared with the controls as well.Conclusion Schizophrenia patients exhibited over connection at high-beta and gamma band in the sensory gating state EEG,the result showed that the brain functional network of schizophrenia patients was impaired as compared with the control subjects.
Keywords：schizophreniaGranger causal analysisdirected transfer functionP50sensory gatinginformation flow gain
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 203-207 )