Research on Correlation Between Generalized Anxiety Disorder and Polymorphism of 5-HT2A Gene in Pilots
Lang Xiaoguang
Liu Hongjin
Cai Qing
Abstract：Objective To study the correlation between T102C and A-1438G polymorphism of 5-Hydroxytryptamine 2A receptor (5-HT2A) gene with generalized anxiety disorder (GAD)in pilots.Methods 5-HT2A gene genotype was assayed with polymerase chain reaction (PCR)in 19 GAD pilots and 55 health control pilots.Results There was no significant difference between GAD pilots and controls in T102C (P ＞ 0.05).There were significant differences between GAD pilots and controls in constituent ratio of A-1438G (P ＜0.05).The frequency of G-1438 allele in GAD pilots (65.8％) was significantly higher than that in controis(34.2％).Conclusion The polymorphisms of A-1438G in 5-HT2A gene may be correlated with GAD in pilots;G-1438 allele may be a susceptible gene for pilots with GAD.
Keywords：pilotsgeneralized anxiety disorder5-Hydroxytryptaminegene polymorphism
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)