Effects of Simulated Weightlessness on Calbindin D-28K-immunoreactivity in Rat Soleus Muscle Spindle(in English)
Abstract：Objective To analyze the mechanism involved in muscle spindle deterioration during simulated weightlessness. Method Using the immunoperoxidase reaction utilizing the ABC (avidin-biotin-complex) method,Calbindin D28K-like immunoreactivity(CaBP-LI) of intrafusal fibres in soleus muscle were detected in 7 d,14 d tail-suspended rats and compared with control rats. Result The extrafusal muscle fibres and nerve fibres did not exhibit immunoreactivity to CaBP. CaBP-LI was found in some of the intrafusal muscle fibres in all the muscle spindles. After 14 d suspension, the immunoreactivity to CaBP of the intrafusal fibres decreased markedly. Conclusion Simulated weightlessness could induce changes in the immunoreactivity of rat soleus muscle spindle to CaBP, which may contribute to the deterioration of muscle spindle.
Keywords：weightlessness simulationcalbindinsoleusmuscle spindlesimmunoactivity
Publication Date：2002-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 313-316 )