Changes of Non-HDL-C and ApoB/ApoA1 in HIV/AIDS Patients After HAART and Their Predictive Value for Cardiovascular System Damage
LIANG Xiaofang
JIANG Zhuo
WANG Lei
MA Fei
Abstract：Objective To investigate the changes of non-high-density lipoprotein cholesterol(non-HDL-C)and apolipoprotein B/apolipoprotein A1 ratio(ApoB/ApoA1)levels during highly active antiretroviral therapy(HAART)in patients with human immunodeficiency virus(HIV)infection/acquired immunodeficiency syndrome(AIDS)and their predictive value for cardiovascular system damage.Methods The clinical data of 400 HIV/AIDS patients admitted to the Fifth People's Hospital of Anyang from January 1,2015 to January 1,2021 were retrospectively analyzed.According to whether HIV/AIDS patients had cardiovascular system damage,they were divided into the occurrence group and the non-occurrence group.The clinical data and the levels of non-HDL-C and ApoB/ApoA1 during treatment were compared between the two groups.Logistic regression analysis was used to analyze the effects of non-HDL-C and ApoB/ApoA1 changes on cardiovascular system damage in HIV/AIDS patients.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of non-HDL-C and ApoB/ApoA1 changes on cardiovascular system damage in HIV/AIDS patients.Results Among the 400 HIV/AIDS patients,112 cases(28.00％)had cardiovascular system damage within 4 years.The main type of damage was abnormal electrocardiogram(86 cases,76.79％),among which non-specific ST-T changes(45 cases)and various arrhythmias(41 cases)were the most common.Imaging abnormalities(18 cases,16.07％)were the second.The proportion of abnormal laboratory tests(8 cases,7.14％)was the lowest,mainly the increase of troponin Ⅰ(5 cases)or creatine kinase isoenzyme(3 cases).The proportion of smoking history and opportunistic infections during treatment in the occurrence group were higher than those in the non-occurrence group.The HAART time was longer than that in the non-occurrence group,and the differences were statistically significant(P＜0.05).The changes of non-HDL-C and ApoB/ApoA1(Δ6 months,Δ12 months)in the occurrence group were higher than those in the non-occurrence group,the differences were statistically significant(P＜0.05).Logistic regression analysis showed that non-HDL-C and ApoB/ApoA1 changes(Δ6 months,Δ12 months)were independently associated with cardiovascular system damage in HIV/AIDS patients(P＜0.05).The area under the curve(AUC)value of non-HDL-C and ApoB/ApoA1(Δ6 months)combined prediction of cardiovascular system damage in HIV/AIDS patients was greater than that of single index prediction(P＜0.05).The AUC value of non-HDL-C and ApoB/ApoA1(Δ12 months)combined prediction of cardiovascular system damage was greater than that of single index prediction(P＜0.05).The AUC value of combined prediction of non-HDL-C and ApoB/ApoA1 change value(Δ12 months)was higher than that of combined prediction of non-HDL-C and ApoB/ApoA1 change value(Δ6 months)(P＜0.05).Conclusion The increase of non-HDL-C and ApoB/ApoA1 levels in HIV/AIDS patients during HAART treatment is related to cardiovascular system damage,and the combination of the changes before and after treatment has a good effect on predicting cardiovascular system damage,which is helpful for clinicians to optimize cardiovascular risk management in time to reduce the occurrence of cardiovascular system damage.
Keywords：human immunodeficiency virusacquired immunodeficiency syndromenon-high-density lipoprotein cholesterolapolipoprotein Bapolipoprotein A1cardiovascular system damagehighly active antiretroviral therapy
Publication Date：2026-08-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：6( 2946-2951 )