Clinical Efficacy of Levosimendan in the Treatment of Acute Episodes of Chronic Heart Failure Complicated with Sleep Disorders and Its Correlation with Psychological State

ZHOU Huiyuan; REN Fengbo; CHEN Ying; WANG Haizhu

doi:10.3969/j.issn.1004-437X.2026.15.031

Abstract：Objective To study the clinical efficacy of levosimendan in patients with acute exacerbation of chronic heart failure(ADHF)complicated with sleep disorders and its association with psychological state.Methods A retrospective study,99 patients with ADHF complicated with sleep disorders who were treated in Zhoukou Central Hospital from January 2021 to December 2023 were selected as the research subjects.According to the treatment regimens recorded in the medical record system,they were divided into the control group(44 cases,conventional treatment)and the study group(55 cases,treatment with levosimedan on the basis of the control group).The heart rate,6-minute walk test distance,serum indicators(brain natriuretic peptide(BNP),carbohydrate antigen 125(CA125),high-sensitivity C-reactive protein(hs-CRP),cardiac function[left ventricular ejection fraction(LVEF),stroke volume(SV),cardiac index(CI),left ventricular fractional shortenin(FS),and cardiac output(CO)],psychological state[(state anxiety inventory(S-AI)and trait anxiety inventory(T-AI)],sleep quality[(Pittsburgh sleep quality index(PSQI)],the incidence of adverse reactions and clinical efficacy of the two groups of patients before and after treatment were compared.The Pearson correlation analysis method was used to analyze the correlation between levosimendan and the scores of psychological state and sleep quality.Results Compared with before treatment,after treatment,the heart rate,CA125,BNP,hs-CRP,S-AI,T-AI and PSQI levels of the patients all decreased,the 6-minute walk test distance and various cardiac function indicators significantly increased(P＜0.05),and the improvement amplitude of the above indicators in the study group was greater than that in the control group(P＜0.05).The total incidence of adverse reactions in the study group was 9.09％(5/55),compared with 6.82％(3/44)in the control group,and the difference was not statistically significant(P＞0.05).The total effective rate of clinical treatment in the study group was 94.55％(52/55),which was higher than that in the control group(77.27％,34/44)(P＜0.05).The results of Pearson correlation analysis showed that the S-AI,T-AI and PSQI after treatment were negatively correlated with the combined levosimendan treatment(r=-0.470,-0.527,-0.503,P＜0.05),suggesting that levosimendan treatment was significantly correlated with psychological state and sleep quality.Conclusion Combined with levosimendan on the basis of conventional treatment can increase the improvement of heart rate,serum indicators,exercise tolerance,cardiac function,anxiety and sleep treatment,without significantly increasing clinical adverse reactions.