Correlation of FAM98A and GMNN Levels with Pathological Characteristics and Prognosis of Endometrial Cancer Patients
QU Hongjie
LU Xiaoqin
ZHANG Yan
LI Yuankun
CAI Lina
Abstract：Objective To explore the correlation between the levels of family with sequence similarity 98 member A(FAM98A)and geminin(GMNN)with pathological characteristics and prognosis of endometrial cancer patients.Methods A total of 94 patients with endometrial cancer admitted to the Second Affiliated Hospital of Zhengzhou University from July 2020 to July 2021 were selected as the study group.They were divided into survival and death patients based on their survival status after 3 years.Another 94 patients with benign tumors were selected as the control group.The expression levels of FAM98A and GMNN and the relative expression levels of FAM98A and GMNN in patients with different pathological features and prognoses of endometrial cancer were compared between the two groups.The correlation between the expression levels of FAM98A and GMNN and pathological features,as well as their predictive value for prognosis and mortality were analyzed.Results The relative expression levels of FAM98A and GMNN in the study group were higher than those in the control group(P＜0.05).The expression levels of FAM98A and GMNN in patients with lymph node metastasis were higher than those in patients without lymph node metastasis.The expression levels of FAM98A and GMNN in patients with stage Ⅰ-Ⅱ were lower than those in patients with stage Ⅲ-Ⅳ.The expression level of FAM98A in patients with muscle invasion depth＞1/2 muscle was higher than that in patients with muscle invasion depth＜1/2 muscle(P＜0.05).The expression levels of FAM98A and GMNN in patients who survived for 3 years were lower than those in patients who died(P＜0.05).The expression levels of FAM98A and GMNN were positively correlated with lymph node metastasis and TNM staging in endometrial cancer patients,and the expression level of FAM98A was positively correlated with the depth of myometrial invasion(P＜0.05).The area under the curve(AUC)of FAM98A,GMNN expression levels,and combined detection for predicting the mortality of endometrial cancer patients were 0.691,0.662,and 0.821,respectively(P＜0.05).Conclusion The levels of FAM98A and GMNN are closely related to lymph node metastasis,TNM staging,and prognosis in patients with endometrial cancer.Combined detection can provide effective reference for clinical prediction of endometrial cancer mortality.
Keywords：endometrial cancerfamily with sequence similarity 98 member Agemininlymph node metastasisTNM stagingprognosis
Publication Date：2026-08-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 2740-2744 )