Effect of Silver Sulfadiazine Ointment Combined with Negative Pressure Technique on Angiogenesis,Staphylococcus aureus and Inflammation in Patients with Diabetic Foot Ulcer
AN Yanchuan
LI Xun
Abstract：Objective To investigate the effects of silver sulfadiazine ointment combined with negative pressure technique on angiogenesis,Staphylococcus aureus and oxidative stress in patients with diabetic foot ulcer.Methods From June 2021 to June 2023,80 patients with diabetic foot ulcer admitted to Puyang People's Hospital were observed.According to different treatment methods,they were divided into routine group(negative pressure technology treatment)and combined group(silver sulfadiazine ointment combined with negative pressure technology treatment),with 40 patients in each group.The levels of angiogenesis and inflammation,bacterial clearance rate,ulcer healing and clinical efficacy were compared between the two groups.Results After treatment,the levels of basic fibroblast growth factor(bFGF)and vascular endothelial growth factor(VEGF)in the combined group were higher than those in the conventional group,while the level of endostatin(ES)was lower,with statistical differences(P＜0.05).After treatment,the superoxide dismutase(SOD)level in the combined group was higher than that in the conventional group,and the malondialdehyde(MDA)level was lower,with a statistical difference(P＜0.05).The bacterial clearance rate of the combined group(90.00％)was higher than that of the conventional group(60.00％),with a statistical difference(P＜0.05).After treatment,the ulcer area of the combined group was smaller than that of the conventional group,and the wound oxygen partial pressure was higher,with statistical differences(P＜0.05).The total effective rate of treatment in the combined group(90.00％)was higher than that in the conventional group(72.50％),with a statistical difference(P＜0.05).Conclusion Silver sulfadiazine ointment combined with negative pressure technology can improve the angiogenesis index and oxidative stress reaction of patients with diabetic foot ulcer,and improve the clearance rate of Staphylococcus aureus.The curative effect is remarkable,which is worthy of clinical application.
Keywords：diabetic foot ulcersilver sulfadiazine ointmentnegative pressure technologyangiogenesisStaphylococcus aureusoxidative stress
Publication Date：2026-07-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 2597-2600 )