Impact of Feeding Mode on the Dynamic Changes of Gut Microbiota in Vaginally Delivered Infant
LIU-DING Jiandi
WANG Xiujuan
MA Xiao
Abstract：Objective To analyze the effects of different feeding mode on the dynamic changes of gut microbial in vaginally delivered infant.Methods A total of 44 vaginally delivered infants in the First Affiliated Hospital of Zhengzhou University from July to August 2017 were enrolled in the study.According to feeding mode,they were divided into the exclusive breastfeeding group(27 cases)and the mixed feeding group(17 cases).Fecal samples were collected at 0 month(meconium)and 3,6,12 months postpartum,and the microbial community diversity and composition was analyzed through high throughput sequencing.Results(1)Compared with exclusive breastfeeding group,the relative abundance of Proteobacteria in mixed feeding group at 12 months significant reduction(Z=2.777,P=0.006).(2)In the two groups,except for mixed feeding group and exclusive breastfeeding group,which Klebsiella and Escherichia-Shigella were dominant respectively at 0 month,Bifidobacterium was dominant at the other three time points.At 0 month,the abundance of Collinsella was increased in mixed feeding group(Z=2.004,P=0.045).At 3 months,the abundance of Scardovia was increased in mixed feeding group(Z=2.778,P=0.006).At 12 months,the abundance of Klebsiella and Enterobacter were lower(Z=2.820,P=0.005;Z=2.560,P=0.011),while that of Blautia increased in mixed feeding group(Z=2.067,P=0.039).Conclusion Significant differences exist in the gut microbial community structure among vaginally delivered infants with different feeding mode.
Keywords：infantfeeding modegut microbiotahigh-throughput sequencing
Publication Date：2026-07-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：7( 2520-2526 )