Effect of Xianyu Capsules Combined with LF-rTMS in Treatment of Primary Epilepsy in Children

CHE Xiaoqing; LIU Weiping; WANG Xinjie

doi:10.3969/j.issn.1004-437X.2026.13.030

Abstract：Objective To investigate the clinical effect of Xianyu Capsule combined with low frequency repetitive transcranial magnetic stimulation(LF-rTMS)in the treatment of primary epilepsy in children.Methods A total of 108 children with primary epilepsy admitted to Luohe Central Hospital from September 2021 to September 2024 were selected as the research objects and divided into two groups according to treatment schemes,with 54 cases in each group.Both groups were treated with sodium valproate.On this basis,the control group was treated with LF-rTMS,and the study group was treated with LF-rTMS and Xianyu Capsule.The efficacy of the two groups of children after treatment,as well as the number of seizures,the quality of life of children's general scale 4.0(PedsQL4.0)score,the average single time,the status epilepticus severity scale(STESS)score,serum factors[calcium,glial fibrillary acidic protein(GFAP),phosphorus,brain-derived neurotrophic factor(BDNF),alkaline phosphatase(ALP),neuron-specific enolase(NSE),insulin-like growth factor-1(IGF-1)]before and after treatment,and adverse reactions were compared.Results There was no significant difference in the total effective rate between the study group[92.59％(50/54)]and the control group[85.19％(46/54)](P＞0.05),but the clinical control rate of the study group[48.15％(26/54)]was higher than that[27.78％(15/54)]of the control group(P＜0.05).After treatment,the average single time,seizure frequency and STESS score of the study group were lower than those of the control group,and the scores of PedsQL4.0 were higher than those of the control group(P＜0.05).After treatment,compared with the control group,BDNF and IGF-1 in the study group were higher,GFAP and NSE was lower(P＜0.05).There was no significant difference in ALP,calcium and phosphorus between the two groups before and after treatment(P＞0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of Xianyu Capsule and LF-rTMS is effective in the treatment of children with primary epilepsy.It can effectively regulate the level of nerve-related factors,improve the clinical symptoms of children,improve the quality of life,and do not increase the burden of bone metabolism.