Effect of Tiaoshen Yunshu Method Combined with Huanglian Wendan Decoction in the Treatment of Post-stroke Depression

LIANG Jianjun; QI Taotao; LUO Shuqing; DOU Lurui; YANG Guang

doi:10.3969/j.issn.1004-437X.2026.13.027

Abstract：Objective To explore the effect of Tiaoshen Yunshu method combined with modified Huanglian Wendan Decoction in the treatment of post-stroke depression(PSD)and its influence on neurotransmitter.Methods A total of 164 patients with PSD in Zhumadian Hospital of Traditional Chinese Medicine Affiliated to Henan University of Traditional Chinese Medicine from September 2023 to October 2025 were selected.They were randomly assigned to conventional group,acupuncture group,decoction group and combined group,with 41 cases in each group.The conventional group was given conventional western medicine treatment,on this basis,the acupuncture group was treated with Tiaoshen Yunshu acupuncture,the decoction group was treated with modified Huanglian Wendan Decoction,and the combined group was treated with Tiaoshen Yunshu acupuncture combined with modified Huanglian Wendan Decoction,all groups were treated continuously for 6 weeks.The therapeutic effect,as well as the depression status score[24 Hamilton depression scale(HAMD-24),self-rating depression scale(SDS)],neurotransmitters[norepinephrine(NE),5-hydroxytryptamine(5-HT),dopamine(DA)]before and after treatment,and adverse reactions were compared among the four groups.Results The total effective rate of the combined group(97.56％)was higher than that of the acupuncture group(80.49％),the decoction group(80.49％)and the conventional group(58.54％)(P＜0.05).The total effective rate of the acupuncture group and the decoction group was higher than that of the conventional group(P＜0.05).After 6 weeks of treatment,the scores of HAMD and SDS in the combined group were lower than those in the acupuncture group,decoction group and conventional group(P＜0.05),and the scores in the acupuncture group and decoction group were lower than those in the conventional group(P＜0.05).After 6 weeks of treatment,the levels of serum 5-HT,NE and DA in the combined group were higher than those in the acupuncture group,decoction group and conventional group(P＜0.05),and those in the acupuncture group and decoction group were higher than those in the conventional group(P＜0.05).There was no significant difference in the incidence of adverse reactions among the four groups(P＞0.05).Conclusion Tiaoshen Yunshu method combined with Huanglian Wendan Decoction can significantly improve the clinical efficacy of PSD patients,and can effectively improve depression.Its effect may be related to the regulation of neurotransmitter levels,and the safety is good.