Interaction Effects of Age and Body Mass Index on the Malignant Risk of Thyroid Nodules and Their Association with C-TIRADS Risk Stratification in a Health Checkup Population
BIAN Miao
MA Wen
YIN Ruihong
Abstract：Objective To explore the interaction effects of age and body mass index(BMI)on the malignant risk of thyroid nodules in health examination populations,and to analyze the correlation between C-TIRADS stratification and malignant risk,so as to provide evidence for standardized thyroid nodule management.Methods A total of 1 126 subjects who underwent physical examination and thyroid ultrasonography from January 2021 to December 2022 were retrospectively enrolled.Baseline information and ultrasonic findings were collected,and thyroid nodules were stratified according to the C-TIRADS system.Statistical analyses including x2 test and binary logistic regression were performed to evaluate the independent and interactive effects of age and BMI on high malignant risk of thyroid nodules.Results The detection rate of high-risk nodules(C-TIRADS≥4)increased significantly with age(P＜0.001).Although the detection rate increased with BMI elevation,no significant difference was observed among BMI groups(P＞0.05).Univariate logistic regression showed that age was significantly correlated with malignant risk(P＜0.001),while BMI had no independent predictive value(P＞0.05).After adjusting for gender,age remained an independent risk factor,and a significant age-BMI interaction was confirmed(P＜0.05).Conclusion Age is independently associated with increased malignant risk of thyroid nodules.BMI cannot independently predict malignant risk but can modulate age-related risk via interaction effect.Middle-aged and elderly individuals with high BMI require intensified surveillance.Combined application of C-TIRADS stratification and metabolic management contributes to precise thyroid health management.
Keywords：thyroid nodulecarcinogenesisagebody mass indexmalignant risk stratificationhealth check-up
Publication Date：2026-07-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：3( 2338-2340 )