Effect of Bromhexine Assisted Prednisone Tablets in the Treatment of Secretory Otitis Media

CUI Lingyun

doi:10.3969/j.issn.1004-437X.2026.12.031

Abstract：Objective To analyze the effect of bromhexidine assisted prednisone tablets in the treatment of secretory otitis media(SOM)and its impact on the serum levels of soluble interleukin-2 receptor(sIL-2R)and Toll-like receptor 2(TLR2)in patients.Methods The data of 150 patients with SOM in Puyang People's Hospital from October 2022 to March 2024 were retrospectively analyzed.Patients were divided into control group and study group according to treatment plans,with 75 cases in each group.The control group was treated with prednisone tablets,while the study group was treated with bromhexine combined with prednisone tablets.Clinical efficacy,symptom recovery time,bone conduction thresholds at different frequencies,tympanic pressure,R-value of pharyngeal manometry,eustachian tube dysfunction 7-item questionnaire(ETDQ-7)score,and serum sIL-2R and TLR2 levels were compared between the two groups.Results The total effective rate of the study group was higher than the control group(P＜0.05).The time of effusion disappearance,tinnitus disappearance and hearing recovery in the study group was shorter than that in the control group(P＜0.05).After treatment,1,2,4 kHz bone conduction threshold,tympanic pressure and ETDQ-7 score in the study group were better than those in the control group,and the R value of eustachian tube pressure at 30,40,50 mbar in the study group was higher than that in the control group(P＜0.05).After treatment,sIL-2R and TLR2 in the study group were lower than those in the control group(P＜0.05).Conclusion Bromhexine has definite therapeutic effect on SOM,which can balance the pressure inside and outside the patient's drum,improve hearing,downregulate the expression of TLR2 and sIL-2R,and promote disease recovery.