Effect of Shenfu Injection Combined with Xuebijing on Hemodynamics and Cellular Immune Function in Patients with Sepsis
ZHAO Zhiqiang
MENG Pengfei
SHI Zhengsong
YAN Yang
WANG Dechang
CHEN Yajun
XIAO Hongtao
ZHANG Xiaoxue
Abstract：Objective To explore the effect of Shenfu injection combined with Xuebijing in patients with sepsis.Methods A total of 80 patients with sepsis who were treated in the First People's Hospital of Zhengzhou from January 2022 to January 2024 were selected as the research subjects and randomly divided into two groups using a random number table method,with 40 patients in each group.On the basis of conventional treatment,the control group was treated with Shenfu injection,while the study group was treated with Shenfu injection combined with Xuebijing.The efficacy and the changes in CD8+,CD4+,erythrocyte sedimentation rate(ESR),CD3+,CD4+programmed cell death molecule 1(PD-1),CD8+PD-1,interleukin-6(IL-6),procalcitonin(PCT),macrophage inflammatory protein 2(MIP-2),fibrinogen(Fib),whole blood viscosity at low shear rate(Nbl),high-sensitivity C-reactive protein(hs-CRP),and whole blood viscosity at high shear rate(Nbh)before and after treatment were compared between the two groups.Results The efficacy grade of the study group was better than that of the control group(P＜0.05),and the marked efficacy rate of 62.50％(25/40)was higher than that of the control group of 35.00％(14/40),but there was no statistically significant difference in the total effective rate between the two groups(P＞0.05).After treatment,the CD3+and CD4+in the study group were higher than those in the control group,while the CD4+PD-1,CD8+PD-1,and CD8+were lower than those in the control group(P＜0.05).After treatment,the hs-CRP,MIP-2,ESR,IL-6,Nbl,Fib,Nbh,and PCT in the study group were lower than those in the control group(P＜0.05).Conclusion The combination of Xuebijing and Shenfu injection in patients with sepsis has a good effect on improving hemodynamics and inhibiting inflammatory reaction,and may also play a role in improving immunity function by regulating the levels of CD8+PD-1,CD4+PD-1 and other factors.
Keywords：sepsisXuebijingShenfu injectioninflammationimmunityprogrammed cell death molecule 1
Publication Date：2026-06-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 2233-2236 )