Mendelian Randomization Study on the Association Between Statin Use and Lung Cancer Risk
ZHOU Fang
HUI Hongyan
XU Zhichao
GAO Jianlian
LIU Xiaohong
DENG Zhijian
Abstract：Objective This study explored the causality between statin use and lung cancer through Mendelian randomization(MR)analysis.Methods Genome-wide association study(GWAS)data of statin use and lung cancer were downloaded from Finnish and integrative epidemiology unit(IEU)open GWAS project database,respectively.MR analysis was performed using methods including inverse-variance weighting(IVW),weighted median,MR Egger,and weighted mode.The heterogeneity,pleiotropy,and sensitivity analysis were also conducted.Results IVW analysis observed a causal association between statin use and lung cancer(OR=0.88,95％CI:0.78-1.00,P=0.042),small cell lung cancer(OR=0.90,95％CI:0.82-0.99,P=0.029),and lung adenocarcinoma(OR=0.94,95％CI:0.90-0.99,P=0.016).Taking statins can reduce the risk of developing lung cancer,small cell lung cancer,and adenocarcinoma of the lung.No causal relationship was found between statin use and lung squamous cell carcinoma(OR=0.95,95％CI:0.89-1.02,P=0.158).Conclusion The use of statins may reduce the risk of lung cancer,potentially having a significant impact on the prevention and treatment of lung cancer.
Keywords：lung cancerstatinMendelian randomization
Publication Date：2026-04-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 1345-1349 )