Clinical Analysis of Febrile Infection-Related Epilepsy Syndrome
JIN Peina
YUAN Wenhua
CHEN Xiaoxin
Abstract：Objective To investigate the clinical features,treatments and outcomes of febrile infection-related epilepsy syndrome.Methods The clinical datas of 17 children with febrile infection-related epilepsy syndrome admitted to Pediatric Intensive Care Unit of the First Affiliated Hospital of Zhengzhou University from August 2017 to June 2022 were retrospectively analyzed.The clinical manifestations,treatments and outcomes were analyzed.Results Among the 17 children with febrile infection-related epilepsy syndrome,there were 8 males and 9 females.The age at onset was(7.09±1.77)years,and the interval time from fever onset to the first seizure was(4.18±1.38)days.The type of seizures was mainly focal seizures.The children were healthy before the onset of the disease,but they all developed frequent seizures or status epilepticus after fever,accompanied by consciousness disorders.During the acute phase,they all received treatment with steroids,gamma globulin,and multiple antiepileptic drugs(4-7 types),but the effects were poor.Ten patients were treated with high-dose phenobarbital,seven patients had significant reduction in seizure frequency but more adverse reactions.The ketogenic diet was tried in seven cases,four of which showed improvement,and one case experienced reduced seizures after receiving tocilizumad treatment.Fourteen children need mechanical ventilation and the time on mechanical ventilation was 15(11.5,25)days,ICU length of stay was 36(31,63)days.Two patients died in the acute phase.At follow-up,only one of eleven was seizure-free and the rest of the patients had refractory epilepsy,nine of them with intellectual disability.Conclusion Febrile infection-related epilepsy syndrome is a catastrophic epileptic encephalopathy with a yet undefined etiology.Multiple antiepileptic drugs and anesthetics have poor therapeutic effect.High-dose phenobarbital is effective in reducing or terminating epileptic seizures,but there are more adverses reactions.Early ketogenic diet and targeted immunotherapy may be effective.Survivors often left with refractory epilepsy and intellectual disability during the chronic phase.
Keywords：refractory epilepsy syndromefeverinfectionchild
Publication Date：2026-04-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 1158-1161 )