Correlation Between Serum CA125,MMP-2 Expression and Postoperative Recurrence of High Grade Cervical Intraepithelial Neoplasia LEEP

ZHAO Yali

doi:10.3969/j.issn.1004-437X.2026.04.011

Abstract：Objective To investigate the correlation between the expression of serum carbohydrate antigen 125(CA125),matrix metalloproteinase 2(MMP-2)and postoperative recurrence in patients with high grade cervical intraepithelial neoplasia(CIN)undergoing loop electrosurgical excision procedure(LEEP).Methods Data were collected from 96 high-grade CIN patients who received LEEP treatment in Henan General Hospital from August 2021 to June 2024.Based on the recurrence status of the patients during one-year follow-up,they were divided into a non recurrence group and a recurrence group.Patient data was reviewed to analyze the correlation between serum CA125 and MMP-2 expression and postoperative recurrence of LEEP in high-grade CIN patients.Results Compared with the non recurrence group,the recurrence group had a higher proportion of glandular lesions,positive margins,persistent postoperative human papilloma virus(HPV)infection,and higher levels of CA125 and MMP-2(P＜0.05).Logistic regression analysis showed that the recurrence of LEEP in high-grade CIN patients was related to the accumulation of lesions,positive surgical margins,persistent postoperative HPV infection,CA125,and MMP-2(OR＞1,P＜0.05).According to the analysis of the restricted cubic spline method,the correlation strength between serum CA1 25,MMP-2 and the risk of recurrence after LEEP in high-grade CIN patients showed a non-linear dose-response relationship(P＜0.05).According to the Phi correlation coefficient analysis,the risk of recurrence in high-grade CIN patients after LEEP was positively correlated with the expression of serum CA125 and MMP-2(P＜0.05).Conclusion Serum CA125 and MMP-2 are highly expressed in high-grade CIN patients with recurrent LEEP,and are significantly positively correlated with the risk of postoperative recurrence.