Therapeutic Effect on Drug-Coated Balloon After Different Pretreatments for Coronary In-Situ Lesions
GENG Yindong
DONG Yanli
ZHANG Yong
JIANG Hui
ZHANG Yujie
LIU Qingxia
Abstract：Objective To investigate the therapeutic effect of drug-coated balloon(DCB)after different preconditions for coronary in-situ lesions.Methods A total of 85 patients with coronary in-situ lesions were selected at Zhengzhou Second People's Hospital from June 2022 to March 2024 for the study.They were divided into a cutting balloon(CB)group(42 cases)and the scoring balloon(SB)group(43 cases)using a random number table method.The CB group was received cutting balloon pretreatment,while the SB group was received scoring balloon pretreatment.The first-pass rate of the balloon,the amount of contrast medium used,the operation time,the incidence of immediate post-operative thrombolysis in myocardial infarction(TIMI)flow ≥ grade 3,the incidence of vascular dissection,no-reflow,and urgent target vessel revascularization(UTVR)were compared between the two groups,as well as the levels of myocardial injury markers[cardiac troponin I(cTnI)and myoglobin(Mb)]before and immediately after surgery,and at 6 months post-surgery.Additionally,the reference vessel diameter(RVD),minimal lumen diameter(MLD),diameter stenosis(DS)rate,and achievement of gain(AG)rate of the vessel were measured before surgery,immediately after surgery,at 6 months post-surgery,and at 1 year post-surgery.The occurrence of major adverse cardiovascular events(MACE)within 1 year post-surgery and the cost-effectiveness ratio[cost-effectiveness ratio(CER)and incremental cost-effectiveness ratio(ICER)]were also evaluated.Results During the postoperative follow-up period,2 cases were lost to follow-up in the CB group and 3 cases in the SB group.Ultimately,40 patients in each group completed the study.The one-time pass rate of the balloon in the SB group was 95.00％,which was higher than that in the CB group(77.50％).The operation time was shorter than that in the CB group(P＜0.05).There were no statistically significant differences in the amount of contrast medium used,the incidence of immediate postoperative TIMI flow at grade 3,vascular dissection,perforation,no-reflow,and incidence of UTVR between the two groups(P＞0.05).Immediately after surgery,the cTnI and Mb levels in the CB group were higher than those in the SB group(P＜0.05).There were no statistically significant differences in RVD between the two groups before surgery,immediately after surgery,6 months after surgery,and 1 year after surgery(P＞0.05).At 6 months and 1 year after surgery,the MLD and AG in the CB group were higher than those in the SB group.The DS was lower than that in the SB group(P＜0.05).There was no statistically significant difference in the incidence of MACE between the two groups during the 1 year follow-up period(P＞0.05).The CER in the SB group was 0.059,which was lower than that in the CB group(0.066).For every additional 1％increase in the patency rate of the CB group,an additional cost of 2 040 yuan was required.Conclusion Both CB and SB pretreatment methods are safe and effective for postoperative vascular patency,but CB exhibits better long-term vascular patency,while SB offers higher cost-effectiveness.Clinically,appropriate pretreatment methods should be selected based on the characteristics of the lesion.
Keywords：coronary in-situ lesiondrug-coated ballooncutting balloonscoring ballooncost-effectiveness
Publication Date：2026-02-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：6( 623-628 )