Correlation Between the Serum Level of CD147 and Carotid Intima-Media Thickness in Patients with Acute Cerebral Infarction
LIU Li
ZHANG Jianlong
CHANG Li
LI Hehua
Abstract：Objective To investigate the correlation between the serum level of CD147 and carotid intima-media thickness(CIMT)in patients with acute cerebral infarction(ACI).Methods A total of 120 ACI patients(ACI group)and 60 healthy controls(control group)admitted to the Department of Neurology of the First Affiliated Hospital of Xinxiang Medical University from May 2022 to March 2023 were enrolled.The difference of serum level of CD147 between the two groups were detected and compared.According to CIMT results,all 120 ACI patients were divided into non-carotid atherosclerosis group(39 cases)and carotid atherosclerosis group(81 cases).According to the presence of carotid plaque and the plaque echo characteristics,all 120 ACI patients were divided into three subgroups:no plaque group(48 cases),stable plaque group(27 cases)and unstable plaque group(45 cases).The correlation between CD147 level and National Institutes of Health stroke scale(NIHSS)score and CIMT in ACI patients was analyzed by Pearson method,the risk factors of CIMT elevation in ACI patients were analyzed by logistic regression,and the clinical efficacy of CD147 level in the diagnosis of carotid atherosclerosis formation in ACI patients was analyzed by receiver operating characteristic(ROC)curve.Results Compared with control group,the expression levels of triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-sensitivity C-reactive protein(hs-CRP),homocysteine,cystatin C and CD147 in ACI group were increased,with statistical significance(P＜0.05).There were significant differences in CD147 expression level and NIHSS score among non-plaque,stable plaque and unstable plaque groups(F=56.450,P＜0.001;F=76.550,P＜0.001).Compared with the non-plaque group,CD147 expression level and NIHSS score were increased in stable plaque group and unstable plaque group(P＜0.05).Compared with stable plaque group,CD147 expression level and NIHSS score in unstable plaque group were increased(P＜0.05).The CD147 expression level in ACI patients were positively correlated with CIMT and NIHSS score(r=0.581,P=0.012;r=0.636,P=0.001).The LDL-C,homocysteine,cystatin C and CD 147 were significantly different between non-carotid atherosclerosis group and carotid atherosclerosis group(P＜0.05).Logistic regression analysis showed that LDL-C(OR=2.472)and CD 147(OR=3.118)were independent risk factors for elevated CIMT in ACI patients.The ROC curve results showed that the AUC of serum CD 147 expression level in the diagnosis of carotid atherosclerosis formation in ACI patients was 0.911,and when the cut-off value was 164.45 ng·L-1,the diagnostic sensitivity and specificity were 89.87％and 92.53％,respectively.Conclusion The serum expression level of CD 147 in ACI patients was significantly increased,which is positively correlated with CIMT.The CD147 may be involved in the pathogenesis of ACI through mediating the formation of carotid atherosclerosis.
Keywords：acute cerebral infarctionCD147atherosclerosiscarotid intima-media thickness
Publication Date：2026-02-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 598-602 )