Predictive Value of Pulmonary Ultrasound Combined with Surfactant Protein A for the Severity of Respiratory Distress Syndrome in Premature Infants
KONG Yan
TANG Chenghe
DING Yuan
LI Ran
Abstract：Objective To explore the predictive value of pulmonary ultrasound combined with surfactant protein A(SP-A)for the severity of respiratory distress syndrome(RDS)in premature infants.Methods One hundred and eight premature infants diagnosed with neonatal respiratory distress syndrome(NRDS)were selected as NRDS group,they were divided into mild group(69 cases)and severe group(39 cases)based on the severity of their condition.Additionally,50 premature infants without NRDS were selected as the control group.The pulmonary ultrasound scores and serum SP-A levels of each group of children were recorded,the receiver operating characteristic(ROC)curve were drew,their predictive value for the severity of RDS in premature infants were calculated.Results The pulmonary ultrasound scores and serum SP-A level in the NRDS group were higher than those in the control group(P＜0.05).The pulmonary ultrasound score and serum SP-A level in children with NRDS increased with the increase of NRDS disease grading,and the differences between groups were statistically significant(P＜0.05).The pulmonary ultrasound scores and serum SP-A level in the severe group were higher than those in the mild group(P＜0.05).The area under the curve(AUC)for predicting the severity of RDS in premature infants using pulmonary ultrasound scores and serum SP-A levels were 0.856(95％CI:0.783-0.930)and 0.889(95％CI:0.813-0.966),respectively.The AUC for the combined detection of the two was 0.937(95％CI:0.879-0.996),which was higher than that of the two alone.The sensitivity(94.90％)and specificity(88.40％)of the combined detection were also higher than those of the two alone.Conclusion The pulmonary ultrasound score and serum SP-A level in children with NRDS are abnormally elevated,and they increase with the increase of NRDS disease grading,their combined detection can further improve the sensitivity and specificity of predicting the severity of RDS in premature infants.
Keywords：premature infantsrespiratory distress syndromepulmonary ultrasoundsurfactant protein Aseverity of illnesspredictive value
Publication Date：2026-02-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：4( 403-406 )