Correlation Between the Serum Expression Level of Chemokine C-X3-C-Motif Ligand 1 and Cognitive Dysfunction in Patients with Cerebral Small Vascular Disease
WANG Fan
WANG Xiangyang
LIU Hao
ZHAO Jianhua
Abstract：Objective To investigate the correlation between serum expression level of chemokine C-X3-C-motif ligand 1(CX3CL1)and cognitive function in patients with cerebral small vascular disease(CSVD).Methods A total of 160 patients with CSVD(CSVD group)and 40 healthy controls(control group)between December 2022 and May 2023 in the First Affiliated Hospital of Xinxiang Medical University were enrolled.The cognitive dysfunction of the patients with CSVD was assessed by Montreal cognitive assessment(MoCA)scale and further divided into MoCA mild group,MoCA moderate group and MoCA severe group.The serum expression level of CX3CL1 was detected by ELISA methods.The correlation between serum expression level of CX3CL1 and MoCA scores was analyzed by Pearson methods.Logistic regression was used to analyze the risk factors of cognitive dysfunction in patients with CSVD.The clinical efficacy of CX3CL1 in diagnosing the cognitive dysfunction in patients with CSVD was analyzed by receiver operating characteristic(ROC)curve.Results Compared with the control group,the serum expression level of CX3CL1 in CSVD group was increased,and the difference was statistically significant(t=43.132,P＜0.001).The serum expression level of CX3CL1 in patients with CSVD complicated without cognitive dysfunction,MoCA score mild group,moderate group and severe group higher expressed successively.The difference was statistically significant(F=56.438,P＜0.001).The correlation analysis results showed that there was a significant negative correlation between serum expression level of CX3CL1 and MoCA score in patients with CSVD(r=-0.640,P=0.003).Compared with the CSVD patients without cognitive dysfunction,triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),uric acid,C-reactive protein,homocysteine and CX3CL1 were increased in CSVD patients with cognitive dysfunction,and the difference was statistically significant(P＜0.05).The uric acid(OR=1.672,P＜0.001),homocysteine(OR=1.891,P＜0.001)and CX3CL1(OR=2.341,P＜0.001)were risk factors for cognitive dysfunction in patients with CSVD.The clinical efficacy of serum expression level of CX3CL1 in the diagnosis of cognitive dysfunction in patients with CSVD was significant.The area under the curve(AUC)was 0.879 and cut-off value of CX3CL1 was 78.34 μg·L-1,the diagnostic sensitivity and specificity were 89.34％and 93.2％,respectively.Conclusion The serum expression level of CX3CL1 in patients with CSVD complicated with cognitive dysfunction is up-regulated.The CX3CL1 can be used as a serological marker in the diagnosis of CSVD complicated with cognitive dysfunction.
Keywords：cerebral small vascular diseasecognitive dysfunctionchemokine C-X3-C-motif ligand 1correlation
Publication Date：2025-12-13
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 4238-4242 )