Effect of Platelet-Rich Fibrin Combined with Orthodontic Treatment on Orthodontic Patients

QIN Guimei; LI Yongyan; JIA Jing; WEI Xiaojing

doi:10.3969/j.issn.1004-437X.2025.20.021

Abstract：Objective To investigate the effect of platelet rich fibrin(PRF)combined with orthodontic treatment on orthodontic patients.Methods A total of 90 orthodontic patients admitted to the Third People's Hospital of Puyang from December 2020 to December 2022 were selected as the research object.Patients were randomly divided into orthodontic group(45 cases)and combined group(45 cases).Among them,orthodontic treatment was given in the orthodontic group,and PRF combined with orthodontic treatment was given in the combined group.The distance of tooth movement,alveolar thickness,tooth function,inflammatory cytokine levels of gingival sulcus fluid[interleukin-6(IL-6),matrix metallo proteinase-8(MMP-8),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]and quality of life were compared between the two groups.Results There were no significant differences in the apex,middle root,gum thickness and arch length of the upper and lower jaw roots before and after the treatment of the two groups(P＞0.05).The width of the upper and lower jaw arches in the joint group was significantly higher than that in the orthodontic group(P＜0.05).Compared with before treatment,the World Health Organization quality of life-BREF(WHOQOL-BREF)scores of dental aesthetics,comfort,language function and chewing function,social relationship,psychology,physiology and environment were significantly increased after treatment,and compared with the orthodontic group,the combined group was increased(P＜0.05).The levels of IL-6,MMP-8,CRP and TNF-α in the two groups were reduced after treatment,and compared with the orthodontic group,the combined group was lower(P＜0.05).Conclusion PRF combined with orthodontic treatment can effectively accelerate tooth movement,improve tooth function,reduce inflammation and improve quality of life.