Changes of Serum Levels of Cav-1,CD62P and E-Selectin After Intravenous Thrombolysis in Patients with Acute Cerebral Infarction and the Prognostic Value of Combined Detection

SONG Shuaizhao; ZHENG Wenquan

doi:10.3969/j.issn.1004-437X.2025.17.019

Abstract：Objective To analyze the changes in serum caveolin protein(Cav-1),P-selectin(CD62P),and E-selectin(E-sele)levels after intravenous thrombolysis in patients with acute cerebral infarction(ACI),and the predictive value of their combination for prognosis.Methods A retrospective study was conducted to select 86 patients with ACI from June 2021 to June 2023 in Pingmei Shenma Medical Group General Hospital as the observation group,and 86 healthy subjects were selected as the control group.The levels of serum Cav-1,CD62P,E-sele,National Institutes of Health stroke scale(NIHSS)score and Brrthal index(BI)score were compared between the two groups at different time points and patients with different prognosis.The correlation was analyzed,and the predictive value of the combination of serum indexes on the prognosis of patients was analyzed.Results The levels of serum Cav-1,CD62P and E-sele in the observation group at 1 day after thrombolysis＞7 days after thrombolysis＞14 days after thrombolysis＞control group(P＜0.05).There were significant differences in serum Cav-1,CD62 P,E-sele levels,NIHSS score and BI score in patients with different prognosis at 7 days and 14 days after thrombolysis(P＜0.05).The levels of serum Cav-1,CD62P and E-sele were positively correlated with NIHSS score and prognosis of patients,and negatively correlated with BI score(P＜0.05).The area under curve(AUC)of combined detection of serum Cav-1,CD62 P and E-sele levels in predicting poor prognosis of ACI patients after intravenous thrombolysis was higher than that of single detection of each index(P＜0.05).Conclusion With the passage of time,the levels of serum Cav-1,CD62P,and E-sele in patients with ACI after thrombolysis have undergone significant changes,and the combined detection of the three has certain predictive value for the prognosis of patients after intravenous thrombolysis.