Prognostic Value of Serum TgAb,VAP-1,and MK in Predicting the Reoperation of Patients with Recurrent/Persistent Differentiated Thyroid Cancer
ZHANG Yiran
WANG Meng
SHEN Sifan
LUO Weiguang
QIAO Hui
ZHENG Peiming
Abstract：Objective To investigate the prognostic value of serum thyroglobulin antibody(TgAb),vascular adhesion protein-1(VAP-1),and midkine(MK)in predicting the prognosis of patients with recurrent/persistent differentiated thyroid cancer(DTC)undergoing reoperation.Methods A total of 200 patients with recurrent/persistent DTC in Henan Provincial People's Hospital from January 2017 to January 2021 were selected as the research subjects.All patients underwent reoperation.Patients were grouped according to their prognosis during the 3-year follow-up period after surgery.They were divided into the poor prognosis group(32 cases)and the good prognosis group(168 cases).The clinical data,serum TgAb,VAP-1,and MK levels were compared between the two groups.The impact and predictive value of serum TgAb,VAP-1,and MK on the prognosis of patients with recurrent/persistent DTC undergoing reoperation was analyzed.Results The age,tumor diameter,pathological stage,lymph node dissection of the poor prognosis group were significantly different from those of the good prognosis group(P＜0.05).The serum TgAb level and MK level in patients with poor prognosis were higher than those in patients with good prognosis,while the serum VAP-1 level was lower in patients with poor prognosis than in patients with good prognosis(P＜0.05).Serum TgAb,VAP-1,and MK remained independent prognostic factors for reoperation in patients with recurrent/persistent DTC(P＜0.05).The area under the curve of serum TgAb,VAP-1,and MK combined to predict the prognosis of patients with recurrent/persistent DTC undergoing reoperation was the highest at 0.925,with the best sensitivity of 87.50％,which was higher than that of single and pairwise combinations of these indicators.Conclusion The abnormal expression of serum TgAb,VAP-1,and MK in patients with recurrent/persistent DTC is closely related to the prognosis of patients undergoing reoperation,and TgAb,VAP-1,and MK can be used to assist in evaluating the prognosis of patients undergoing reoperation.
Keywords：thyroid cancerrecurrence/persistent differentiatedthyroglobulin antibodyvascular adhesion protein-1midkinereoperationprognosis
Publication Date：2025-08-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 2930-2934 )