Therapeutic Effect of Resection Arthroplasty Combined with Calcium Sulfate Antibiotic Granules for Knee Fungal Periprosthetic Joint Infection
ZHANG Shaokun
GE Hui'an
LU Shitao
LIU Yongyi
XU Jianzhong
Abstract：Objective To investigate the effect of resection arthroplasty combined with calcium sulfate antibiotic granules for knee fungal periprosthetic joint infection.Methods From January 2019 to December 2022,the date of 13 patients[6 males and 7 females,age of(67.9±11.2)years]with knee fungal fungal periprosthetic joint infection had undergone resection arthroplasty combined with calcium sulfate antibiotic granules implantation was retrospective analysis.Calcium sulfate granules containing amphotericin B were implanted into the joint cavity during operation,and antifungal drugs were administered postoperatively.Synovial fluid was collected for microorganism culture and analysis of drug sensitivity preoperatively.Range of motion(ROM),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),and Hospital for Special Surgery knee-rating scale(HSS)score were regularly evaluated during follow-up.Results The follow-up period ranged from 24 to 65 months and the mean of follow-up time were 47.2 months.The infection of 11 patients was cured after once treatment,with no recurrence occurring up to the last follow-up.However,two patients experienced infection recurrence during the follow-up period,with the infection being cured after re-treatment.The infection recovery rate of once treatment was 84.62％.Five patients were infected with Candida parapsilosis,three with Candida glabrata,and two with Candida albicans.Candida accounted for infection in 76.92％of patients.ROM was improved from(48.57±20.69)° to(94.29±22.01)°.HSS score was increased from 44.93±8.58 preoperatively to 87.21±6.17 at the last follow-up.At the last follow-up,no patients had any symptoms of recurrence of infection,and ESR and CRP were within the normal ranges.Conclusion Resection arthroplasty combined with calcium sulfate antibiotic granules can achieve a satisfactory therapeutic effect for knee fungal fungal periprosthetic joint infection,with a higher rate of infection recovery and more significant improvement of knee function.
Keywords：resection arthroplastyfungal infectionknee jointperiprosthetic infectioncalcium sulfate
Publication Date：2025-08-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：6( 2895-2900 )